Window Theory in Non-Ionizing Radiation-Induced Adaptive Responses

Window theory in non-ionizing radiation-induced adaptive responses.

The dose window for radiation-induced protective adaptive responses.

Adaptive responses to low doses of low LET radiation occur in all organisms thus far examined, from single cell lower eukaryotes to mammals. These responses reduce the deleterious consequences of DNA damaging events, including radiation-induced or spontaneous cancer and non-cancer diseases in mice. The adaptive response in mammalian cells and mammals operates within a certain window that can be...

Effects of quercetin on ionizing radiation-induced cellular responses in HepG2 cells

Background: Quercetin has been reported to modulate cell proliferation and apoptosis. The present study aimed at identifying whether treatment of ionizing radiation (IR) combined with quercetin induces apoptosis in HepG2 cells. Materials and Methods: HepG2 cells were plated at an appropriate density according to each experimental scale and irradiated with 1, 5 and 10 Gy gamma-rays from a 60Co s...

Adaptive response in human blood lymphocytes exposed to non-ionizing radiofrequency fields: resistance to ionizing radiation-induced damage

The aim of this preliminary investigation was to assess whether human peripheral blood lymphocytes which have been pre-exposed to non-ionizing radiofrequency fields exhibit an adaptive response (AR) by resisting the induction of genetic damage from subsequent exposure to ionizing radiation. Peripheral blood lymphocytes from four healthy donors were stimulated with phytohemagglutinin for 24 h an...

Ionizing Radiation Induced Radicals

When ionizing radiation passes through a material it imparts some of its energy to that material. The imparted energy may be high enough to cause a break in bonds inside the molecules or between molecules or both, in such cases, free radicals are created. The type, lifetime, extent, fate and origin of those free radicals may differ according to several factors; most of them are beyond the subje...